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Dobroslawa Bialonska, Ph.D.

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Title: Assistant Professor of Environmental Microbiology
Phone: 706-864-1787
Email:

Office: Health & Natural Sciences 437, Dahlonega
Areas of Expertise: Environmental microbiology, Natural products in drug development, Human gut microbiota, Food microbiology

Courses Taught

  • BIOL1107K Principles of Biology I
  • BIOL 2500/L Microbiology for Allied Health Professionals 
  • BIOL4836 Environmental Microbiology

Education

  • Ph.D., Jagiellonian University, Krakow, Poland, 2004
  • Master in Science, Jagiellonian University, Krakow, Poland, 1999

Research/Special Interests

Quorum Sensing Inhibition

Bacteria can communicate with each other via quorum sensing (QS). This communication allows bacteria to determine bacterial density in a given area and then change their gene expression when a large enough group is detected. Many bacterial activities have been shown to be QS-regulated including toxin production, biofilm formation, and light production.  If the process of QS can be interrupted it is possible that bacteria could be rendered less pathogenic (QSI). We use the bacterium Chromobacterium violaceum as a model organism, because it produces a purple pigment if QS is reached or remains colorless if QS is inhibited. Currently, we are testing a group of novel pyrrolobenzodiazepines (PBD) for their QS inhibitory activity.

Bioactive Natural Products: Detection, Isolation and Structure Determination

Natural products are chemical compounds produced by a living organism. They are produced as a result of ecological interactions with abiotic and biotic environment and often exhibit profound biological activity (antimicrobial, antitumoral, antioxidant, etc.). In fact, approximately 60% of drugs available on market originate from natural products either in original or modified form.  We’re extracting secondary metabolites from plants, fungi and bacteria to test them for antimicrobial and antioxidant properties.

Analyses of microbial populations on patient owned wheelchairs and therapeutic ball pits.  

Since we are aware that germs are being identified in hospitals on wheelchairs that the hospitals have, we wanted to look at what organisms might be on wheelchair users who are out in the community.  Similarly, the equipment for ball pits has reached the public’s attention in places like McDonald’s where there are public play areas, but there is no specific research that looks at ball pits that are used in therapeutic environments such as outpatient clinics for children. This project is performed in cooperation with Dr. Andy Robinson from the Department of Physical Therapy. To identify bacteria we use BIOLOG system that analyzes ability of the cell to metabolize all major classes of biochemicals. 

Publications

Ranpura, H.; Bialonska, D; Bolton, P.H. Finding and characterizing the complexes of drug like molecules with quadruplex DNA: Combined use of an enhanced hydroxyl radical cleavage protocol and NMR. PLOS ONE. 2014, DOI: 10.1371/journal.pone.0096218.

Lewellyn, K.; Bialonska, D.; Loria, M.J.; White, S.W.; Sufka, K.J.; Zjawiony, J.K. In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model. Bioorg. Med. Chem. Lett.  2013, 21:7083-7090.

Chaurasiya, N.D.; Lewellyn, K.; Bialonska, D.; Zjawiony J.; Tekwani B.L. Mechanism and kinetics of inhibition of human MAO A and B by aplysinopsin analogs. Planta Med.  2012, 78: P_104.

Lewellyn, K.; Bialonska, D.; Chaurasiya, N.D.; Tekwani, B.L.; Loria, M.J.; White, S.W.; Sufka, K.J.; Zjawiony, J.K. In vitro and in vivo evaluation of the antidepressant activity of aplysinopsin analogs. Planta Med. 2012, 78 - CL22

Lewellyn, K.; Bialonska, D.; Chaurasiya N.D.; Tekwani, B.L.; Zjawiony, J.K. Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B. Bioorg. Med. Chem. Lett.  2012, 22:4926-4929.

Bialonska, D.; Song, K.; Bolton, P.H. Complexes of mismatched and complementary DNA with minor groove binders. Structures at nucleotide resolution via an improved hydroxyl radical cleavage methodology. Mutat. Res. 2011, 726, 47-53.

Jurkiewicz, A.; Ryszka,P.; Anielska, T.; Waligórski, P.; Bialonska, D.; Góralska, K.; Tsimilli-Michael, M.; Turnau, K. Optimization of culture conditions of Arnica montana L.: effects of mycorrhizal fungi and competing plants.Mycorrhiza 2010, 20, 293-306.

Bialonska, D.; Ramnani, P.; Kasimsetty, S.G.; Gibson, G.R.; Ferreira, D. The influence of pomegranate by-product and punicalagins on the human faecal microbiota. Int. J. Food Microbiol. 2010, 140, 175-182.

Bialonska, D.; Kasimsetty, S.G.; Khan S.I.; Ferreira, D. Urolithins, intestinal microbial metabolites of pomegranate ellagitannins, exhibit potent antioxidant activity in a cell based assay. J. Agric. Food Chem. 2009, 57, 10181-10186.

Bialonska, D.; Kasimsetty, S.G.; Schrader, K.K.; Ferreira, D. The effect of pomegranate (Punica granatum L.) byproducts and ellagitannins on the growth of human gut bacteria. J. Agric. Food Chem. 2009, 57, 8344-8349.

Kasimsetty, S.G.; Bialonska, D.; Muntha, K.R.; Ma, G.; Ferreira, D. Antiproliferative and apoptotic effects of pomegranate chemical constituents/microbial metabolites in HT-29 human colon cancer cells. J. Agric. Food Chem. 2010, 58, 2180-2187.

Kasimsetty, S.G.; Bialonska, D.; Muntha, K.R.; Willett, K.L.; Ferreira, D. Effects of pomegranate chemical constituents/microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells. J. Agric. Food Chem. 2009, 57, 10636-10644. 

Bialonska, D.; Zjawiony, J. K. Aplysinopsins - Marine Indole Alkaloids: Chemistry, Bioactivity and Ecological Significance. Mar. Drugs 2009, 7, 166-183.

Bialonska, D.; Zobel, A.M.; Kuras, M.; Tykarska, T.; Sawicka-Kapusta, K. Phenolic compounds and cell structure in bilberry leaves affected by emissions from a Zn-Pb smelter. Water Air Soil Pollut. 2007, 187: 123-133.

Bialonska, D.; Dayan, F. Chemistry of lichen Hypogymnia physodes transplanted to an industrial region. J. Chem. Ecol. 2005, 31, 2975-2991.

Work Experience

  • Assistant Professor of Biology, Morningside College, Sioux City IA, August 2013 – August 2014.
  • Visiting Assistant Professor of Biology, St. Edward’s University, Austin TX, August 2012 - May 2013.
  • Postdoctoral Associate, Wesleyan University, Middletown CT, March 2010 – August 2012.
  • Postdoctoral Associate, The University of Mississippi, School of Pharmacy, Oxford MS, February 2007 – July 2009. 

Personal Information

Dr. Bialonska was born and grew up in Poland. She first arrived to the US in 2003 as a graduate scholar to conduct research in the School of Pharmacy, University of Mississippi, where she later worked as a postdoctoral research associate. Dr. Bialonska loves to spend time with her husband, daughter, and her Yorkie. She enjoys yoga, jogging, reading, and is passionate of traveling. She has visited 15 countries in Europe and North America. In future she would love to travel with UNG students for a study abroad in Europe.

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