Cell Biology Research

To determine mechanisms of immune cell regulation.

• ELISA
• Cell culture
• Animal models
• Cell activity assays
• Microscopy

Bian Z, Shi L, Guo YL, Lv Z, Tang C, Niu S, Tremblay, A, et al. 2016. Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proceedings of the National Academy of Sciences of the United States of America 113(37):E5434-43.

To model human diseases, such as infertility and neurodegeneration, in Drosophila melanogaster.

• Bioinformatics
• Genome editing
• Western blotting
• Immunofluorescence microscopy
• Behavior assay

Hudson A, Parrott BB, Qian Y, Schulz C. 2013. A temporal signature of epidermal growth factor signaling regulates the differentiation of germline cells in testes of Drosophila melanogaster. PLoS One 8(8):e70678.

Qian Y, Ng CL, Schulz C. 2015. CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila Melanogaster. Developmental Biology 398(1):68-79.

Qian Y, Dominado N, Zoller R, Ng C, et al. 2014. Ecdysone signaling opposes epidermal growth factor signaling in regulating cyst differentiation in the male gonad of Drosophila Melanogaster. Developmental Biology 394(2):217-27.