Cell Biology Research

To determine mechanisms of immune cell regulation.

• ELISA
• Cell culture
• Animal models
• Cell activity assays
• Microscopy

Bian Z, Shi L, Guo YL, Lv Z, Tang C, Niu S, Tremblay, A, et al. 2016. Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proceedings of the National Academy of Sciences of the United States of America 113(37):E5434-43.

The effect of natural agricultural products on the growth of cancer cells.

• Tissue culture work
• MTT assays
• Western blotting
• Immunohistochemistry
• Bioinformatics

Rhodes, S., Short, S., Sharma, S., Kaur, R., & Jha, M. (2019). One-pot mild and efficient synthesis of [1,3]thiazino[3,2-a]indol-4-ones and their anti-proliferative activity. Org Biomol Chem, 17(16), 3914-3920.

Mittal K, Donthamsetty S, Kaur R, et al. 2017. Multinucleated polyploidy drives resistance to Docetaxel chemotherapy in prostate cancer. British Journal of Cancer 116(9):1186-1194.

Mittal K, Choi DH, Klimov S, Pawar S, Kaur R, et al. 2016. A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian
adenocarcinomas. J Ovarian Res 18(9):17.

Shashidharamurthy R, Bozeman EN, Patel J, Kaur R, et al. 2012. Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development. Medicinal Research Reviews 32(6):1197-219.

Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, et al. 2008. Effective use of PI3K and MEK inhibitors to treat mutant K-Ras G12D and PIK3CA H1047R murine lung cancers. Nat Med.14(12):1351-6.

Kaur R, Yuan X, Lu ML, Balk SP. 2008. Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate 68(14):1510-6.

To model human diseases, such as infertility and neurodegeneration, in Drosophila melanogaster.

• Bioinformatics
• Genome editing
• Western blotting
• Immunofluorescence microscopy
• Behavior assay

Hudson A, Parrott BB, Qian Y, Schulz C. 2013. A temporal signature of epidermal growth factor signaling regulates the differentiation of germline cells in testes of Drosophila melanogaster. PLoS One 8(8):e70678.

Qian Y, Ng CL, Schulz C. 2015. CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila Melanogaster. Developmental Biology 398(1):68-79.

Qian Y, Dominado N, Zoller R, Ng C, et al. 2014. Ecdysone signaling opposes epidermal growth factor signaling in regulating cyst differentiation in the male gonad of Drosophila Melanogaster. Developmental Biology 394(2):217-27.