Cell Biology Research
Dahlonega Campus
Alexandra Tremblay, Ph.D.
Main Research Goals
To determine mechanisms of immune cell regulation.
Potential Roles for Students
- ELISA
- Cell culture
- Animal models
- Cell activity assays
- Microscopy
Relevant Publications
Bian Z, Shi L, Guo YL, Lv Z, Tang C, Niu S, Tremblay, A, et al. 2016. Cd47-Sirpα interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proceedings of the National Academy of Sciences of the United States of America 113(37):E5434-43.
Gainesville Campus
Main Research Goals
The effect of natural agricultural products on the growth of cancer cells.
Potential Roles for Students
- Tissue culture work
- MTT assays
- Western blotting
- Immunohistochemistry
- Bioinformatics
Relevant Publications
Mittal K, Donthamsetty S, Kaur R, et al. 2017. Multinucleated polyploidy drives resistance to Docetaxel chemotherapy in prostate cancer. British Journal of Cancer 116(9):1186-1194.
Mittal K, Choi DH, Klimov S, Pawar S, Kaur R, et al. 2016. A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian
adenocarcinomas. J Ovarian Res 18(9):17.
Shashidharamurthy R, Bozeman EN, Patel J, Kaur R, et al. 2012. Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development. Medicinal Research Reviews 32(6):1197-219.
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, et al. 2008. Effective use of PI3K and MEK inhibitors to treat mutant K-Ras G12D and PIK3CA H1047R murine lung cancers. Nat Med.14(12):1351-6.
Kaur R, Yuan X, Lu ML, Balk SP. 2008. Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate 68(14):1510-6.
Mittal K, Choi DH, Klimov S, Pawar S, Kaur R, et al. 2016. A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian
adenocarcinomas. J Ovarian Res 18(9):17.
Shashidharamurthy R, Bozeman EN, Patel J, Kaur R, et al. 2012. Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development. Medicinal Research Reviews 32(6):1197-219.
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, et al. 2008. Effective use of PI3K and MEK inhibitors to treat mutant K-Ras G12D and PIK3CA H1047R murine lung cancers. Nat Med.14(12):1351-6.
Kaur R, Yuan X, Lu ML, Balk SP. 2008. Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate 68(14):1510-6.
Main Research Goals
The effects of cigarette smoking on breast and bladder cancer development as well as effects of tobacco use on public health.
Potential Roles for Students
- Immunohistochemistry
- Immunocytochemistry
- Cell culture
- Public health research
Relevant Publications
Kispert S, Schwartz T, McHowat J. 2017. Cigarette smoke regulates calcium-independent phospholipase A2 metabolic pathways in breast cancer. The American Journal of Pathology 187(8):1855-1866.
Kispert S, Crawford S, Kolar G, McHowat J. 2017. In vivo effects of long-term cigarette smoke exposure on mammary tissue in mice. The American Journal of Pathology 187(6):1238-1244.
Kispert S, Marentette JO, McHowat J. 2014. Enhanced breast cancer cell adherence to the lung endothelium via PAF acetylhydrolase inhibition: a potential mechanism for enhanced metastasis in smokers. American Journal of Physiol Cell Physiol 307(10):C951-6.
Kispert S, Crawford S, Kolar G, McHowat J. 2017. In vivo effects of long-term cigarette smoke exposure on mammary tissue in mice. The American Journal of Pathology 187(6):1238-1244.
Kispert S, Marentette JO, McHowat J. 2014. Enhanced breast cancer cell adherence to the lung endothelium via PAF acetylhydrolase inhibition: a potential mechanism for enhanced metastasis in smokers. American Journal of Physiol Cell Physiol 307(10):C951-6.
Main Research Goals
To model human diseases, such as infertility and neurodegeneration, in Drosophila melanogaster.
Potential Roles for Students
- Bioinformatics
- Genome editing
- Western blotting
- Immunofluorescence microscopy
- Behavior assay
Relevant Publications
Hudson A, Parrott BB, Qian Y, Schulz C. 2013. A temporal signature of epidermal growth factor signaling regulates the differentiation of germline cells in testes of Drosophila melanogaster. PLoS One 8(8):e70678.
Qian Y, Ng CL, Schulz C. 2015. CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila Melanogaster. Developmental Biology 398(1):68-79.
Qian Y, Dominado N, Zoller R, Ng C, et al. 2014. Ecdysone signaling opposes epidermal growth factor signaling in regulating cyst differentiation in the male gonad of Drosophila Melanogaster. Developmental Biology 394(2):217-27.
Qian Y, Ng CL, Schulz C. 2015. CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila Melanogaster. Developmental Biology 398(1):68-79.
Qian Y, Dominado N, Zoller R, Ng C, et al. 2014. Ecdysone signaling opposes epidermal growth factor signaling in regulating cyst differentiation in the male gonad of Drosophila Melanogaster. Developmental Biology 394(2):217-27.