Cell Biology Research
Dahlonega Campus
Alexandra Tremblay, Ph.D.
Main Research Goals
To determine mechanisms of immune cell regulation.
Potential Roles for Students
- ELISA
- Cell culture
- Animal models
- Cell activity assays
- Microscopy
Relevant Publications
Gainesville Campus
Main Research Goals
The effect of natural agricultural products on the growth of cancer cells.
Potential Roles for Students
- Tissue culture work
- MTT assays
- Western blotting
- Immunohistochemistry
- Bioinformatics
Relevant Publications
Rhodes, S., Short, S., Sharma, S., Kaur, R., & Jha, M. (2019). One-pot mild and efficient synthesis of [1,3]thiazino[3,2-a]indol-4-ones and their anti-proliferative activity. Org Biomol Chem, 17(16), 3914-3920.
Mittal K, Donthamsetty S, Kaur R, et al. 2017. Multinucleated polyploidy drives resistance to Docetaxel chemotherapy in prostate cancer. British Journal of Cancer 116(9):1186-1194.
Mittal K, Choi DH, Klimov S, Pawar S, Kaur R, et al. 2016. A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian
adenocarcinomas. J Ovarian Res 18(9):17.
Shashidharamurthy R, Bozeman EN, Patel J, Kaur R, et al. 2012. Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development. Medicinal Research Reviews 32(6):1197-219.
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, et al. 2008. Effective use of PI3K and MEK inhibitors to treat mutant K-Ras G12D and PIK3CA H1047R murine lung cancers. Nat Med.14(12):1351-6.
Kaur R, Yuan X, Lu ML, Balk SP. 2008. Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. Prostate 68(14):1510-6.
Main Research Goals
The effects of cigarette smoking on breast and bladder cancer development as well as effects of tobacco use on public health.
Potential Roles for Students
- Immunohistochemistry
- Immunocytochemistry
- Cell culture
- Public health research
Relevant Publications
Kispert S, Crawford S, Kolar G, McHowat J. 2017. In vivo effects of long-term cigarette smoke exposure on mammary tissue in mice. The American Journal of Pathology 187(6):1238-1244.
Kispert S, Marentette JO, McHowat J. 2014. Enhanced breast cancer cell adherence to the lung endothelium via PAF acetylhydrolase inhibition: a potential mechanism for enhanced metastasis in smokers. American Journal of Physiol Cell Physiol 307(10):C951-6.
Main Research Goals
To model human diseases, such as infertility and neurodegeneration, in Drosophila melanogaster.
Potential Roles for Students
- Bioinformatics
- Genome editing
- Western blotting
- Immunofluorescence microscopy
- Behavior assay
Relevant Publications
Qian Y, Ng CL, Schulz C. 2015. CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila Melanogaster. Developmental Biology 398(1):68-79.
Qian Y, Dominado N, Zoller R, Ng C, et al. 2014. Ecdysone signaling opposes epidermal growth factor signaling in regulating cyst differentiation in the male gonad of Drosophila Melanogaster. Developmental Biology 394(2):217-27.